{"id":120,"date":"2011-07-21T08:34:48","date_gmt":"2011-07-21T08:34:48","guid":{"rendered":"http:\/\/nalaz.senkahukic.com\/?p=119"},"modified":"2018-10-25T20:10:36","modified_gmt":"2018-10-25T20:10:36","slug":"laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba","status":"publish","type":"post","link":"https:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/","title":{"rendered":"Laboratorijske metode u predikciji razvoja karcinoma grli\u0107a maternice \u2013 NASBA"},"content":{"rendered":"<p><!--:bs--><\/p>\n<p style=\"text-align: center;\"><strong>NOVI KORACI U DIJAGNOSTICI HPV INFEKCIJE<\/strong><\/p>\n<p style=\"text-align: center;\"><strong>LABORATORIJSKE METODE U PREDIKCIJI RAZVOJA KARCINOMA GRLI\u0106A MATERNICE \u2013 NASBA<\/strong><\/p>\n<p><strong><em>Mr.sci. biomed. Irma Salimovi\u0107- Be\u0161i\u0107, MSc. biohemije<\/em><\/strong><\/p>\n<p>Zavod za biomedicinsku dijagnostiku i istrazivanje NALAZ posebnu pa\u017enju posve\u0107uje reproduktivnom zdravlju \u017eena. Posebno mjesto u dijagnostici Zavoda NALAZ zauzima dijagnostika infekcije sa humanim papilomavirusom (HPV) i predvi\u0111anje toka i ishoda infekcije. Zavod za biomedicinsku dijagnostiku NALAZ je jedina ustanova u BiH, koja posjeduje NASBA tehnologiju i koji mo\u017ee na osnovu mjerenja nivoa mRNA za protein E6 i E7 virusa, pratiti aktivnost virusa i odrediti momenat kada perzistentna infekcija prelazi u invazivnu, koja dovodi do nastanka karcinoma.<\/p>\n<p><strong>HPV i karcinom grli\u0107a materice<\/strong><\/p>\n<p>Karcinom grli\u0107a materice je uzrokovan kod 99,7% slu\u010dajeva dugotrajnom (perzistentnom) infekcijom humanim papilomavirusom (HPV) (1). Ve\u0107ina takvih infekcija je prolaznog karaktera i ne dovodi do razvoja karcinoma grli\u0107a materice. Me\u0111utim, mali ali zna\u010dajan broj HPV infekcija napreduje do takvog karcinoma (Slika 1). Prekomjernom sintezom virusnih onkoproteina E6 i E7 se naru\u0161avaju kontrolni mehanizmi \u0107elijskog ciklusa, \u0161to dovodi do maligne transformacije i prekanceroznih promjena \u0107elija (2) (Slika 2). Istra\u017eivanja sprovedena na uzorcima karcinoma grli\u0107a materice su pokazala da su genotipovi HPV-16 i HPV-18 zastupljeni u pribli\u017eno 70% slu\u010dajeva \u0161irom svijeta (3).<\/p>\n<p><a href=\"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba2-388x198.png\"><img decoding=\"async\" class=\"lazyload size-medium wp-image-10876 aligncenter\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27300%27%20height%3D%27153%27%20viewBox%3D%270%200%20300%20153%27%3E%3Crect%20width%3D%27300%27%20height%3D%27153%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba2-388x198-300x153.png\" alt=\"nasba2-388x198\" width=\"300\" height=\"153\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Slika 1. Prikaz karaktera HPV infekcije.<\/p>\n<p><a href=\"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba3-388x198.png\"><img decoding=\"async\" class=\"lazyload size-medium wp-image-10877 aligncenter\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27300%27%20height%3D%27153%27%20viewBox%3D%270%200%20300%20153%27%3E%3Crect%20width%3D%27300%27%20height%3D%27153%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba3-388x198-300x153.png\" alt=\"nasba3-388x198\" width=\"300\" height=\"153\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Slika 2. Nastanak karcinoma preko niza prekanceroznih promjena usljed HPV infekcije<\/p>\n<p><strong>Da li su dijagnosti\u010dke metode zasnovane na detekcije virusne (HPV) DNA adekvatan izbor za prognozu pojave karcinoma grli\u0107a materice?<\/strong><\/p>\n<p>Dijagnosti\u010dke metode zasnovane na detekciji virusnog genoma (HPV DNA) pokazuju samo da je virus prisutan u \u0107eliji, ali ne daju informaciju o onkogenoj aktivnosti virusa, niti da li infekcija ima prolazni ili dugotrajan karakter. Novije tehnologije preporu\u010duju nove koncepte koji se vi\u0161e fokusiraju na detekciju specifi\u010dnijih faktora rizika- poput otkrivanja nivoa izra\u017eavanja virusnih onkogena E6 i E7, koji imaju klju\u010dnu ulogu u malignoj transformaciji inficirane \u0107elije. Nivo izra\u017eavanja gena se mjeri detekcijom mRNA.<\/p>\n<p><strong>Koji tip testa ima ve\u0107u medicinsku prediktivnu vrijednost?<\/strong><\/p>\n<p>Detekcija mRNA onkoproteina HPV E6 i E7 je potvrda toga, da je u inficiranoj \u0107eliji prisutna dugotrajna sinteza virusnih onkoproteina, te da infekcija nema samo prolazni karakter. Stoga, ovakav na\u010din testiranja ima mnogo ve\u0107i klini\u010dki zna\u010daj jer trija\u017eira pacijentice koje su pod direktnim rizikom od razvoja karcinoma grli\u0107a materice. Medicinska prediktivna vrijednost detekcije HPV E6\/E7 mRNA je ve\u0107a u odnosu na testove zasnovane samo na otkrivanju prisustva HPV infekcije DNA testiranjem (4,5). Pokazalo se da se uz pomo\u0107 mRNA testiranja mo\u017ee isklju\u010diti ve\u0107i broj \u017eena sa normalnom citologijom i histologijom, tj., da test ima bolje parametre za isklju\u010divanje pacijentica koje nisu pod rizikom od razvoja karcinoma grli\u0107a materice (6).<\/p>\n<p><strong>\u0160ta sa pacijenticama ispod 30 godina starosti?<\/strong><\/p>\n<p>Po\u0161to je kod pacijentica mla\u0111ih od 30 godina ve\u0107a zastupljenost prolaznih HPV infekcija, izbor HPV DNA testa kod ove populacije je od upitnog klini\u010dkog zna\u010daja. Zbog toga su testovi detekcije mRNA i dugotrajne virusne onkogene aktivnosti od mnogo ve\u0107eg prognosti\u010dkog i klini\u010dkog zna\u010daja kod ove populacije \u017eena u odnosu na metode detekcije virusne DNA (7).<\/p>\n<p><em>Preporu\u010deni algoritam za selekciju \u017eena sa citolo\u0161kim promjenama ASCUS\/LSIL svih starosnih dobi dat je na slici 3.<\/em><\/p>\n<p style=\"text-align: center;\"><a href=\"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba-300x2611.png\"><img decoding=\"async\" class=\"lazyload size-medium wp-image-10875 aligncenter\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27300%27%20height%3D%27261%27%20viewBox%3D%270%200%20300%20261%27%3E%3Crect%20width%3D%27300%27%20height%3D%27261%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba-300x2611-300x261.png\" alt=\"nasba-300x261\" width=\"300\" height=\"261\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Slika 3. Skrining program za otkrivanje promjena na grli\u0107u materice preporu\u010den od strane Danske Administracije za zdravlje (8)<\/p>\n<p><strong>Druge mogu\u0107e indikacije za E67E7 mRNA testiranje<\/strong>:<\/p>\n<ul>\n<li>Testiranje HPV DNA pozitivnih \u017eena (iz primarnog skrininga)<\/li>\n<li>Pra\u0107enje pacijentica nakon lije\u010denja<\/li>\n<li>Skrining HIV+ pacijentica<\/li>\n<li>Skrining i pra\u0107enje karcinoma koji nisu na grli\u0107u materice<\/li>\n<li>Pra\u0107enje poslije vakcinacije<\/li>\n<\/ul>\n<p><strong>Reference<\/strong>:<\/p>\n<ol>\n<li>Walboomers J et al, Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J. Pathol. 1999; 189:12-19.<\/li>\n<li>Zur Hausen et al, Papillomaviruses and cancer: from basic studies to clinical application. Nat. Rev. Cancer 2002; 2:342-50.<\/li>\n<li>Kahn et al, The elevated 10-year risk of high risk of cercical cancer in women with HPV type 16 or 18. J. Nat. Cancer Inst 2005; Vol. 97, n\u00b014.<\/li>\n<li>Molden et al, Comparaison of HPV mRNA and DNA detection: a cross-sectional study of 4136 women &gt;30 years of age with a 2-years follow-up of high grade sqamous intraepithelial lesion, Int. J. Cancer 2005; 114:973-976.<\/li>\n<li>Cuschieri et al, HPV type specific DNA and RNA persistence-implications for cervical Disease Progression and monitoring, J. Med. Virol.2004; 73:65-70.<\/li>\n<li>Lie et al, DNA- versus RNA-based methods for HPV detection in cervical neoplasia Gynec. Onc. 2005; 97: 908-915.<\/li>\n<li>Molden et al, HPV E6\/E7 mRNA expression in women younger than 30 years of age, Gynec. Onc. 2006; 100:95-100.<\/li>\n<li>Screening for Cervical Cancer. Sundhedsstyrelsen, Denmark, 2007.<\/li>\n<\/ol>\n<p><!--:--><!--:en--><\/p>\n<p style=\"text-align: center;\"><strong>NEW STEPS IN DIAGNOSIS OF HPV INFECTION<\/strong><\/p>\n<p style=\"text-align: center;\"><strong>THE LABORATORY METHODS TO PREDICT THE DEVELOPMENT OF CERVICAL CANCER \u2013 NASBA<\/strong><\/p>\n<p><em>Mr.sci.biomed. Irma Salimovi\u0107- Be\u0161i\u0107, MSc. of biochemistry<\/em><\/p>\n<p>Institute for biomedical diagnostics and research- NALAZ pays close attention to the reproductive health of women. A special place in the diagnostics there occupies diagnosis of human papillomavirus (HPV) infection and predicting the course and outcome of infection. Institute for biomedical diagnostics and research- NALAZ is the only institution in B&amp;H, which owns the NASBA technology and who can, based on measuring the levels of mRNA for viral oncoproteins E6 and E7, monitor virus activity and determine the moment when persistent infection becomes invasive, leading to the emergence of cancer.<\/p>\n<p><strong>HPV and cervical cancer<\/strong><\/p>\n<p>Cervical cancer is caused by the long-term (persistent) high-risk HPV infection in 99,7% of cases (1). Most HPV infections are transient and do not lead to cancer of the cervix. However, a small but significant number of HPV infections progress to such cancers (Figure 1). Excessive synthesis of viral oncoproteins E6 and E7 disrupt the mechanisms controlling the cell cycle, leading to malignant transformation of precancerous changes in infected cells (2) (Figure 2). Researches carried out on samples of cervical carcinoma showed that the genotypes of HPV-16 and HPV-18 are represented in approximately 70% of cases worldwide (3).<\/p>\n<p><a href=\"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba2-388x198.png\"><img decoding=\"async\" class=\"lazyload size-medium wp-image-10876 aligncenter\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27300%27%20height%3D%27153%27%20viewBox%3D%270%200%20300%20153%27%3E%3Crect%20width%3D%27300%27%20height%3D%27153%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba2-388x198-300x153.png\" alt=\"nasba2-388x198\" width=\"300\" height=\"153\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Figure 1. Course of HPV infection.<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba3-388x198.png\"><img decoding=\"async\" class=\"lazyload size-medium wp-image-10877 aligncenter\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27300%27%20height%3D%27153%27%20viewBox%3D%270%200%20300%20153%27%3E%3Crect%20width%3D%27300%27%20height%3D%27153%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba3-388x198-300x153.png\" alt=\"nasba3-388x198\" width=\"300\" height=\"153\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Figure 2. Cancer development through a series of precancerous changes caused by HPV infection (2)<\/p>\n<p><strong>Are the diagnostic methods based on the detection of virus (HPV) DNA adequate choice for prediction of occurrence of cervical carcinoma?<\/strong><\/p>\n<p>Diagnostic methods based on the detection of viral genome (HPV DNA) indicate only that the virus is present in the cell, but does not provide information on viral oncogenic activity, or that the infaction has transient or long-lasting character. Current technologies suggest new concepts that are focused on detection of more specific risk factors- such as the detection of overexpression of viral oncogenes E6 and E7, which play a critical role in malignant transformation of the infected cells. The level of gene expression is measured by detecting the gene transcripts (mRNA) in this case.<\/p>\n<p><strong>What type of test has greater medical predictive value?<\/strong><\/p>\n<p>mRNA detection of HPV oncoproteins E6 and E7 is a confirmation of the fact, that the infected cell established long-term synthesis of viral oncoproteins, and that infection is not only temporary. Therefore, such a test has a much greater clinical significance due to efficient triage of the patients who are under the direct risk of developing cervical cancer. Medical predictive value of detection of HPV E6\/E7 mRNA was higher compared to tests based only on detecting the presence of HPV infection (detecting the viral genome) (4,5). It turned out that testing for the overexpression of HPV oncogenes can exclude a larger number of women with normal cervical cytology and histology, i.e., that test has a better performance for the exclusion of women who are not at risk of developing cervical cancer (6).<\/p>\n<p><strong>How to manage the women under 30 years of age?<\/strong><\/p>\n<p>Women under the age of 30 have higher prevalence of transient HPV infections and HPV DNA testing in this population is of questionable clinical significance. Therefore, detection of oncogenic HPV mRNA and consequently persistant viral oncogenic activity is of higher predictive and clinical value in relation to methods of detection of viral DNA for this population of women (7).<\/p>\n<p><em>Recommanded algorithm for women of all ages with cytology results ASCUS\/LSIL is given in figure 3.<\/em><\/p>\n<p style=\"text-align: center;\"><a href=\"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba-300x2612.png\"><img decoding=\"async\" class=\"lazyload size-medium wp-image-10878 aligncenter\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27300%27%20height%3D%27261%27%20viewBox%3D%270%200%20300%20261%27%3E%3Crect%20width%3D%27300%27%20height%3D%27261%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba-300x2612-300x261.png\" alt=\"nasba-300x261\" width=\"300\" height=\"261\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Figure 3. Screening programme to detect changes in the cervix recommended by the Danish Administration of Health (8)<\/p>\n<p><strong>Other possible indications for implementing E67\/E7 mRNA testing<\/strong>:<\/p>\n<ul>\n<li>Testing of HPV DNA positive women (from primary screening)<\/li>\n<li>Monitoring of patients after therapy<\/li>\n<li>Screening of HIV+ patients<\/li>\n<li>Screening and monitoring of non-cervical cancers<\/li>\n<li>Following after HPV vaccination<\/li>\n<\/ul>\n<p>References:<\/p>\n<ol>\n<li>Walboomers J et al, Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J. Pathol. 1999; 189:12-19.<\/li>\n<li>Zur Hausen et al, Papillomaviruses and cancer: from basic studies to clinical application. Nat. Rev. Cancer 2002; 2:342-50.<\/li>\n<li>Kahn et al, The elevated 10-year risk of high risk of cercical cancer in women with HPV type 16 or 18. J. Nat. Cancer Inst 2005; Vol. 97, n\u00b014.<\/li>\n<li>Molden et al, Comparaison of HPV mRNA and DNA detection: a cross-sectional study of 4136 women &gt;30 years of age with a 2-years follow-up of high grade sqamous intraepithelial lesion, Int. J. Cancer 2005; 114:973-976.<\/li>\n<li>Cuschieri et al, HPV type specific DNA and RNA persistence-implications for cervical Disease Progression and monitoring, J. Med. Virol.2004; 73:65-70.<\/li>\n<li>Lie et al, DNA- versus RNA-based methods for HPV detection in cervical neoplasia Gynec. Onc. 2005; 97: 908-915.<\/li>\n<li>Molden et al, HPV E6\/E7 mRNA expression in women younger than 30 years of age, Gynec. Onc. 2006; 100:95-100.<\/li>\n<li>Screening for Cervical Cancer. Sundhedsstyrelsen, Denmark, 2007.<\/li>\n<\/ol>\n<p><!--:--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>NOVI KORACI U DIJAGNOSTICI HPV INFEKCIJE LABORATORIJSKE METODE U PREDIKCIJI RAZVOJA KARCINOMA GRLI\u0106A MATERNICE \u2013 NASBA Mr.sci. biomed. Irma Salimovi\u0107- Be\u0161i\u0107, MSc. biohemije Zavod za biomedicinsku dijagnostiku i istrazivanje NALAZ posebnu pa\u017enju posve\u0107uje reproduktivnom zdravlju \u017eena. Posebno mjesto u dijagnostici Zavoda NALAZ zauzima dijagnostika infekcije sa humanim papilomavirusom (HPV) i predvi\u0111anje toka i ishoda infekcije.  [&#8230;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[32],"class_list":["post-120","post","type-post","status-publish","format-standard","hentry","category-novosti","tag-nasba"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Laboratorijske metode u predikciji razvoja karcinoma grli\u0107a maternice \u2013 NASBA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Laboratorijske metode u predikciji razvoja karcinoma grli\u0107a maternice \u2013 NASBA\" \/>\n<meta property=\"og:description\" content=\"NOVI KORACI U DIJAGNOSTICI HPV INFEKCIJE LABORATORIJSKE METODE U PREDIKCIJI RAZVOJA KARCINOMA GRLI\u0106A MATERNICE \u2013 NASBA Mr.sci. biomed. Irma Salimovi\u0107- Be\u0161i\u0107, MSc. biohemije Zavod za biomedicinsku dijagnostiku i istrazivanje NALAZ posebnu pa\u017enju posve\u0107uje reproduktivnom zdravlju \u017eena. Posebno mjesto u dijagnostici Zavoda NALAZ zauzima dijagnostika infekcije sa humanim papilomavirusom (HPV) i predvi\u0111anje toka i ishoda infekcije. [...]\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/\" \/>\n<meta property=\"og:site_name\" content=\"NALAZ\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/labnalaz\" \/>\n<meta property=\"article:published_time\" content=\"2011-07-21T08:34:48+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-10-25T20:10:36+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba2-388x198-300x153.png\" \/>\n<meta name=\"author\" content=\"administrator\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"administrator\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/#article\",\"isPartOf\":{\"@id\":\"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/\"},\"author\":{\"name\":\"administrator\",\"@id\":\"https:\/\/www.nalaz.org\/v2\/#\/schema\/person\/533010352873009f9e917792d9e5b154\"},\"headline\":\"Laboratorijske metode u predikciji razvoja karcinoma grli\u0107a maternice \u2013 NASBA\",\"datePublished\":\"2011-07-21T08:34:48+00:00\",\"dateModified\":\"2018-10-25T20:10:36+00:00\",\"mainEntityOfPage\":{\"@id\":\"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/\"},\"wordCount\":1542,\"publisher\":{\"@id\":\"https:\/\/www.nalaz.org\/v2\/#organization\"},\"image\":{\"@id\":\"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/#primaryimage\"},\"thumbnailUrl\":\"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba2-388x198-300x153.png\",\"keywords\":[\"NASBA\"],\"articleSection\":[\"Novosti\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/\",\"url\":\"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/\",\"name\":\"Laboratorijske metode u predikciji razvoja karcinoma grli\u0107a maternice \u2013 NASBA\",\"isPartOf\":{\"@id\":\"https:\/\/www.nalaz.org\/v2\/#website\"},\"primaryImageOfPage\":{\"@id\":\"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/#primaryimage\"},\"image\":{\"@id\":\"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/#primaryimage\"},\"thumbnailUrl\":\"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba2-388x198-300x153.png\",\"datePublished\":\"2011-07-21T08:34:48+00:00\",\"dateModified\":\"2018-10-25T20:10:36+00:00\",\"breadcrumb\":{\"@id\":\"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/#primaryimage\",\"url\":\"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba2-388x198-300x153.png\",\"contentUrl\":\"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba2-388x198-300x153.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.nalaz.org\/v2\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Laboratorijske metode u predikciji razvoja karcinoma grli\u0107a maternice \u2013 NASBA\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.nalaz.org\/v2\/#website\",\"url\":\"https:\/\/www.nalaz.org\/v2\/\",\"name\":\"www.nalaz.org\",\"description\":\"Zavod za biomedicinsku dijagnostiku i ispitivanje NALAZ\",\"publisher\":{\"@id\":\"https:\/\/www.nalaz.org\/v2\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.nalaz.org\/v2\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.nalaz.org\/v2\/#organization\",\"name\":\"NALAZ\",\"url\":\"https:\/\/www.nalaz.org\/v2\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.nalaz.org\/v2\/#\/schema\/logo\/image\/\",\"url\":\"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2015\/11\/nalaz-logoRetina.png\",\"contentUrl\":\"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2015\/11\/nalaz-logoRetina.png\",\"width\":300,\"height\":98,\"caption\":\"NALAZ\"},\"image\":{\"@id\":\"https:\/\/www.nalaz.org\/v2\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/labnalaz\",\"https:\/\/www.linkedin.com\/company\/nalaz\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.nalaz.org\/v2\/#\/schema\/person\/533010352873009f9e917792d9e5b154\",\"name\":\"administrator\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.nalaz.org\/v2\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c41329f6ced017d226ccaf86f8b87818b122469c9286b3900d873825f937fc81?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c41329f6ced017d226ccaf86f8b87818b122469c9286b3900d873825f937fc81?s=96&d=mm&r=g\",\"caption\":\"administrator\"},\"url\":\"https:\/\/www.nalaz.org\/v2\/author\/administrator\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Laboratorijske metode u predikciji razvoja karcinoma grli\u0107a maternice \u2013 NASBA","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/","og_locale":"en_US","og_type":"article","og_title":"Laboratorijske metode u predikciji razvoja karcinoma grli\u0107a maternice \u2013 NASBA","og_description":"NOVI KORACI U DIJAGNOSTICI HPV INFEKCIJE LABORATORIJSKE METODE U PREDIKCIJI RAZVOJA KARCINOMA GRLI\u0106A MATERNICE \u2013 NASBA Mr.sci. biomed. Irma Salimovi\u0107- Be\u0161i\u0107, MSc. biohemije Zavod za biomedicinsku dijagnostiku i istrazivanje NALAZ posebnu pa\u017enju posve\u0107uje reproduktivnom zdravlju \u017eena. Posebno mjesto u dijagnostici Zavoda NALAZ zauzima dijagnostika infekcije sa humanim papilomavirusom (HPV) i predvi\u0111anje toka i ishoda infekcije. [...]","og_url":"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/","og_site_name":"NALAZ","article_publisher":"https:\/\/www.facebook.com\/labnalaz","article_published_time":"2011-07-21T08:34:48+00:00","article_modified_time":"2018-10-25T20:10:36+00:00","og_image":[{"url":"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba2-388x198-300x153.png","type":"","width":"","height":""}],"author":"administrator","twitter_card":"summary_large_image","twitter_misc":{"Written by":"administrator","Est. reading time":"8 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/#article","isPartOf":{"@id":"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/"},"author":{"name":"administrator","@id":"https:\/\/www.nalaz.org\/v2\/#\/schema\/person\/533010352873009f9e917792d9e5b154"},"headline":"Laboratorijske metode u predikciji razvoja karcinoma grli\u0107a maternice \u2013 NASBA","datePublished":"2011-07-21T08:34:48+00:00","dateModified":"2018-10-25T20:10:36+00:00","mainEntityOfPage":{"@id":"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/"},"wordCount":1542,"publisher":{"@id":"https:\/\/www.nalaz.org\/v2\/#organization"},"image":{"@id":"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/#primaryimage"},"thumbnailUrl":"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba2-388x198-300x153.png","keywords":["NASBA"],"articleSection":["Novosti"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/","url":"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/","name":"Laboratorijske metode u predikciji razvoja karcinoma grli\u0107a maternice \u2013 NASBA","isPartOf":{"@id":"https:\/\/www.nalaz.org\/v2\/#website"},"primaryImageOfPage":{"@id":"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/#primaryimage"},"image":{"@id":"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/#primaryimage"},"thumbnailUrl":"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba2-388x198-300x153.png","datePublished":"2011-07-21T08:34:48+00:00","dateModified":"2018-10-25T20:10:36+00:00","breadcrumb":{"@id":"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/#primaryimage","url":"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba2-388x198-300x153.png","contentUrl":"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2011\/07\/nasba2-388x198-300x153.png"},{"@type":"BreadcrumbList","@id":"http:\/\/www.nalaz.org\/v2\/laboratorijske-metode-u-predikciji-razvoja-karcinoma-grlica-maternice-nasba\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.nalaz.org\/v2\/"},{"@type":"ListItem","position":2,"name":"Laboratorijske metode u predikciji razvoja karcinoma grli\u0107a maternice \u2013 NASBA"}]},{"@type":"WebSite","@id":"https:\/\/www.nalaz.org\/v2\/#website","url":"https:\/\/www.nalaz.org\/v2\/","name":"www.nalaz.org","description":"Zavod za biomedicinsku dijagnostiku i ispitivanje NALAZ","publisher":{"@id":"https:\/\/www.nalaz.org\/v2\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.nalaz.org\/v2\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.nalaz.org\/v2\/#organization","name":"NALAZ","url":"https:\/\/www.nalaz.org\/v2\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.nalaz.org\/v2\/#\/schema\/logo\/image\/","url":"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2015\/11\/nalaz-logoRetina.png","contentUrl":"http:\/\/www.nalaz.org\/v2\/wp-content\/uploads\/2015\/11\/nalaz-logoRetina.png","width":300,"height":98,"caption":"NALAZ"},"image":{"@id":"https:\/\/www.nalaz.org\/v2\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/labnalaz","https:\/\/www.linkedin.com\/company\/nalaz"]},{"@type":"Person","@id":"https:\/\/www.nalaz.org\/v2\/#\/schema\/person\/533010352873009f9e917792d9e5b154","name":"administrator","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.nalaz.org\/v2\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c41329f6ced017d226ccaf86f8b87818b122469c9286b3900d873825f937fc81?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c41329f6ced017d226ccaf86f8b87818b122469c9286b3900d873825f937fc81?s=96&d=mm&r=g","caption":"administrator"},"url":"https:\/\/www.nalaz.org\/v2\/author\/administrator\/"}]}},"_links":{"self":[{"href":"https:\/\/www.nalaz.org\/v2\/wp-json\/wp\/v2\/posts\/120","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nalaz.org\/v2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nalaz.org\/v2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nalaz.org\/v2\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nalaz.org\/v2\/wp-json\/wp\/v2\/comments?post=120"}],"version-history":[{"count":1,"href":"https:\/\/www.nalaz.org\/v2\/wp-json\/wp\/v2\/posts\/120\/revisions"}],"predecessor-version":[{"id":11824,"href":"https:\/\/www.nalaz.org\/v2\/wp-json\/wp\/v2\/posts\/120\/revisions\/11824"}],"wp:attachment":[{"href":"https:\/\/www.nalaz.org\/v2\/wp-json\/wp\/v2\/media?parent=120"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nalaz.org\/v2\/wp-json\/wp\/v2\/categories?post=120"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nalaz.org\/v2\/wp-json\/wp\/v2\/tags?post=120"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}